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Although alendronate increased femoral-neck and trochanter bone density, etidronate had a protective effect only at the trochanter (but did not increase bone mineral density).

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Black DM, Thompson DE, Bauer DC, Ensrud K, Musliner T, Hochberg MC, Nevitt MC, Suryawanshi S, SR C 2000 Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial.

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The relationship between breast cancer survival and prior postmenopausal estrogen use.

No specific information is available on the treatment of overdosage with FOSAMAX.

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Caution needed in patients with history of upper gastrointestinal disorders (discontinue if symptoms worsen); ulcers and active gastrointestinal bleeding.

Olpadronate: a new amino-bisphosphonate for the treatment of medical osteopathies.

What are the possible side effects of alendronate (Binosto, Fosamax)?

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Fosamax to increase warning about possible atypical femur fracture side effect.

Foods rich in calcium include dairy products, spinach, sardines, and nuts.

B12 are too high according to my blood test.

Estrogen replacement therapy is often prescribed for women at menopause.

Drug therapies include bisphosphonates, parathyroid hormone, raloxifene, estrogen, and calcitonin.

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Sit upright or stand upright until at least 30 minutes have passed and you have eaten your first food of the day.

This effect of calcium is likely to be physicochemical, not only as a constituent of apatite but also in the initiation (nucleation) through binding to elastin and through formation of nascent crystals in matrix vesicles.

The disease is characterized by tenderness and a dull, aching pain.

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The United States, Australia, and New Zealand have high prevalence rates because of significant populations with northern European ancestry and a large population of British immigrants.

Varma is currently Ted Hartman Chair in Medical Education and Vice-Chair of Pediatrics at Texas Tech University Health Sciences Center.

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HR-pQCT and DXA measurements), relevant nonbone outcomes (body mass and body mass index), and potential confounders (total daily intake of calcium and vitamin D and physical activity levels).

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Although the process of bone thinning is a natural part of aging and cannot be completely stopped, there are measures that can and should be taken early to prevent or delay osteoporosis.

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MK-7 at 180μg daily for three years has resulted in increased bone mineral density of the lumbar spine and femoral neck (but not hip) yet all around improvements in bone strength.

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GRADE approach because it measures domains contributing to the overall assessment of risk of bias which were not assessed by Jadad scale: such as blinding for the outcome assessor, selective outcome reporting and “other sources” of bias.

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The key is to be aware of these medications and their impact on osteoporosis.

Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs.

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It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to alendronate.

Eldecalcitol, in Combination with Bisphosphonate, Is Effective for Treatment of Japanese Osteoporotic Patients.

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After each use, safely remove the needle, recap the delivery device, and put it back in the refrigerator right away.

Fortunately, ocular symptoms usually resolve within a few weeks after bisphosphonate discontinuation.

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When you stop taking the osteoporosis drugs, the free flowing drug gets eliminated via the urine in a few months (drink plenty of fluids to accelerate this process) and as bone remodeling starts again, new bone will cover the old bone to which the drug attached itself and will render the drug inactive.

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It is not known whether alendronate is excreted in human milk.

Patient education about delayed bone healing and the long rehabilitation process is important in situations of fracture and postsurgery.

CUA (in abstract form only) in humans, but in the largest study to date, warfarin use was not associated with increased CAC.

This medicine may increase your risk of developing fractures of the thigh bone.

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Glynn and her husband, Richard Glynn, sued Merck in September 2011, alleging that Fosamax causes serious and fatal injuries.

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In healthy adults, high sodium intake has been associated with increased fractional intestinal calcium absorption and a rise in PTH and vitamin D-3 levels.

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It is thought that topical phylloquinone epoxide, rather than phylloquinone itself, is more effective due to being less allergenic and susceptable to heat or light damage.

This finding is consistent with the fact that the prevalence of vertebral fractures at base line was three times as high in the etidronate study and may also reflect the effects of higher doses of calcium and vitamin D in our study (the patients in the etidronate study received only 500 mg of calcium per day and no vitamin D supplement).

Bisphosphonates Bisphosphonates, the most commonly used medications used to treat osteoporosis, decrease the activity of bone-dissolving cells.

This has been known to occur very rarely in patients who have been taking alendronate for some time.

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In addition to Fosamax (alendronate sodium), the other medications are Didronel (etidronate disodium), Aredia (pamidronate disodium), Skelid (tiludronate disodium), Actonel (risedronate sodium), and Reclast (zoledronic acid).

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Since their introduction to clinical practice more than 3 decades ago, bisphosphonates have been increasingly used for an array of skeletal disorders.

For those who are at risk for osteoporosis or already have the disease, treatment may help boost bone mass and prevent (further) bone loss.

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The benefits of calcium supplement on the bone density of prepubertal girls remain unknown.

Finally, alendronate appears to offer a comparable level of protection without the concerns of osteosarcoma.

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Also, all trials evaluating drug therapies for osteoporosis use DXA measurements as inclusion criteria.

Osteoporosis medications can also be very costly.

Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis.

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As previously noted, osteoporosis is a clinically heterogeneous disease with a range of origins, including hormone loss (postmenopausal and androgen-deprivation), iatrogenic (glucocorticoid-induced and transplant-related), physical (immobility), and genetic (eg, juvenile and OI-associated).

These changes result in progressive bone loss and lead to osteoporosis in a significant proportion of women over age 50.

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However, physicians have been limited in the prescription of bisphosphonates for osteoporotic older patients because of concerns of concomitant renal impairment, which is common is this population.

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Ensuring adequate calcium and vitamin D intake both before and after initiation of bisphosphonate therapy is an extremely important but frequently overlooked aspect of providing optimal care of skeletal health.

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So knowing that appropriate calcium levels help maintain cognitive function and balance, it can be concluded that bisphosphonates increase your risk of falls and subsequent fractures.

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